FGS resulted in decreased recurrence compared with BLS (33% versus 62%, P = 0.049) and lengthened disease-free median survival from 9 to >36 wk. All mice with primary tumor that had undergone FGS had complete resection compared with 58% of mice in the BLS group (P = 0.001). Pre- and post-operative images with the OV-100 Small Animal Imaging System (Olympus Corp, Tokyo Japan) were obtained to assess the extent of surgical resection. Tumors were resected under bright light surgery (BLS) or FGS. We established fluorescent orthotopic mouse models of human colon cancer expressing a fluorescent protein. We inquired if fluorescence-guided surgery (FGS) could improve surgical outcomes in fluorescent orthotopic nude mouse models of human colon cancer. Metildi, Cristina A Kaushal, Sharmeela Snyder, Cynthia S Hoffman, Robert M Bouvet, Michael (authors)įluorescence-guided surgery of human colon cancer increases complete resection resulting in cures in an orthotopic nude mouse model. Conclusions: Anti-EGFR therapy enhances the radiosensitivity of human lung adenocarcinoma xenograft in nude mouse. Sensitizing enhancement ratio of combination group was 1.5 in growth and 1.7 in regrowth. Tumor regrowth delay time in combination therapy and irradiation alone groups was 23.4 and 10.2 days. Results: For A549 xenografts in radiation alone, gefitinib alone and combination therapy groups, the percentage of tumor growth inhibition was 22.7%, 12.4% and 38.2%, respectively (F=25.75, P=0.000). Percentage of tumor growth inhibition, growth delay time and regrowth delay time were evaluated.

Tumor diameter was measured every other day. In the combination group, radiotherapy was performed 2 hours after Gefitinib administration. Gefitinib was daily administered by gavage at 100 mg/(kgÂ

Radiation schedule was 3 fractions of 5 Gy, once daily. The mice were derided into 4 groups: control, irradiation alone, Gefinitib alone and radiation combined with Genifitib. Methods: Human lung adenocarcinoma cell line A549 was used to establish nude mouse xenograft tumor model. Objective: To investigate the effect of Gefitinib on radiosensitivity of human lung adenocarcinoma xenograft in nude mouse. Wang Hui Li Tianran Tian Jiahe Qu Baolin Zhu Hui International Nuclear Information System (INIS) The effect ofÂ .Īnti-EGFR therapy radiosensitizes human lung adenocarcinoma xenograft in nude mouse Xenogen in vivo imaging system was used to monitor tumor growth and metastasis. Methods: Withaferin A was injected through a portal vein to the orthotopic liver tumor in a nude mice model. Purpose: To investigate the effect of withaferin A on tumor growth and metastasis in liver in a nude mouse model. Withaferin A Suppresses Liver Tumor Growth in a Nude Mouse.

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